Effects of glucose infusion on dog myocardial metabolism.

OUR knowledge of the role of glucose in the metabolism of the heart in the whole animal appears to be restricted to its extraction from circulating blood and its effect on glycogen elevation, despite extensive studies in isolated tissue and organ preparations. In this study the myocardial ''.oritent of high energy phosphate compounds, estimated as acid-labile phosphate, was examined following infusion of glucose to the whole dog. In addition, the concentrations of inorganic phosphate, glycogen, lactate, potassium and sodium were determined. The possibility that glucose infusion may have a salutary effect on the metabolism of the coronary-occluded heart was also investigated.